In relieving vaginal dryness, couples do not want to create another problem. However, most personal lubricants and even saliva can harm sperm. Research conducted on personal lubricants over the past three decades has clearly demonstrated their detrimental effects on sperm (Figure 1).
Since Pre~seed® was first introduced in 2002, other lubricant products claiming to be “fertility- or conception-friendly” have been introduced. However, a recent study found that only the Pre~seed® formula did not impact the ability of sperm to fertilise or support normal embryo development, where as several other “fertility” lubricants caused a decline in fertilisation and embryo growth rates in an animal model.
How Do Other Products Damage Sperm?
The reason for sperm damage from most products can be seen when data on product pH and osmolarity are compared as in the table below.
The optimum pH value for sperm migration and survival in the cervical mucus is between 7.1 and 8.5 (according to the World Health Organization Manual 4th edition, 2000). Sperm are very sensitive to low (acidic) pH and, to a lesser extent, elevated (alkaline) pH. Below pH levels of 6.9, sperm die at a rate that increases with lowering pH.
Sperm are also sensitive to both high and low osmolarities (ion concentration in solution). A physiologic osmolarity between 260-360 mOsm/kg (that of semen) is best for sperm function.
(Adapted from: Rossato M, et al. Role of seminal osmolarity in the regulation of human sperm motility. International Journal of Andrology. 2002; 25: 230-235.)
Usually ingredients like glycerin or propylene glycol (in most lubricants), are what result in these high osmolarities. We have tested many products besides the ones shown here. If any glycols or mineral oils are in the lubricant you are using, you can pretty much assume the formula will be damaging to sperm.
Water also kills sperm on contact because it has no salt solution. Some people will tell you to use a little warm water--- don’t’!
Likewise, saliva has digestive enzymes in it that stop sperm from swimming on contact—not so good if you want them to reach the egg!
Even mineral oil which some doctors recommend, has been shown to limit the ability of sperm to penetrate eggs in laboratory studies (likely due to the high osmolarity as shown in this Table).
Additionally, none of these other lubricants have 510(k) clearance by FDA with labeling for use during fertility interventions, or as safe for use by couples who are trying to conceive (Learn More).
Astroglide® is a product of BioFilm, Inc.
K-Y® is a product of McNeil-PPC, Inc.
Pre~Seed® is a product of INGfertility, LLC
K-Y® is a product of McNeil-PPC, Inc.
Pre~Seed® is a product of INGfertility, LLC
(Figure 1).
Intercourse on demand around ovulation can lead to anxiety and increased vaginal dryness. In fact, 75% of TTC couples report an increased frequency of vaginal dryness.
Trying to conceive (TTC) is a big issue. At least 90 million couples worldwide, 11 million in the US alone, are trying to become pregnant.
With only a 20% average chance of becoming pregnant each cycle, it's no surprise that couples can become stressed.
With only a 20% average chance of becoming pregnant each cycle, it's no surprise that couples can become stressed.
Vaginal Dryness When 'Baby Making'
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